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 |  | May 1, 2008 Abbott, Takeda Conclude TAP Joint Venture |  |
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 |  | Apr 29, 2008 Sucampo Pharmaceuticals Obtains FDA Approval for AMITIZA® for the Treatment of Irritable Bowel Syndrome with Constipation in Adult Women |  |
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 |  | Mar 31, 2008 New Data Showed ACTOS® (pioglitazone HCl) Prevented Progression of Atherosclerotic Plaque Volume in Patients with Type 2 Diabetes |  |
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 |  | Mar 19, 2008 Takeda Announces New U.S. Leadership |  |
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 |  | Mar 19, 2008 Takeda, Abbott Announce Plans to Conclude TAP Joint Venture |  |
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 |  | Jan 4, 2008 Takeda Submits New Drug Application for Alogliptin (SYR-322) in the U.S. |  |
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 |  | Nov 6, 2007 “Move to AMITIZA” Advertising Campaign Underscores the Power of Not Letting Chronic Constipation Slow People Down |  |
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 |  | Oct 24, 2007 Student Scientists Receive Scholarships to Advance Research |  |
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 |  | Sep 11, 2007 Takeda Statement on ACTOS® (pioglitazone HCl) Meta-Analysis Published in the Journal of the American Medical Association |  |
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 |  | Jul 30, 2007 Takeda Responds to the FDA Advisory Committee Recommendation |  |
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 |  | Jul 12, 2007 Sucampo Pharmaceuticals Submits Supplemental New Drug Application for Lubiprostone to Treat Irritable Bowel Syndrome with Constipation |  |
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 |  | Jun 19, 2007 U.S. Green Building Council Awards Takeda U.S. Home Office LEED Gold Environmental Certification |  |
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 |  | Jun 6, 2007 Takeda Revises ACTOS® (pioglitazone HCl) Prescribing Label |  |
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 |  | May 22, 2007 New Study Suggests No Significant Impairment in Middle-of-the-Night Balance, Mobility or Memory in Older Adults Using Ramelteon |  |
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 |  | May 21, 2007 New Study Demonstrates that Lubiprostone May Improve Symptom Relief Rates in Adults with Irritable Bowel Syndrome with Constipation (IBS-C) |  |
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 |  | May 14, 2007 Takeda Expands Support of Community Health and Wellness Initiatives in Partnership with Two Local Not-for-Profit Organizations |  |
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 |  | Feb 26, 2007 Takeda and TAP to Promote Sucampo's AMITIZA in the United States |  |
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 |  | Jan 19, 2007 Takeda Global Research & Development Center, Inc. Names Dr. Mehmood Khan President |  |
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 |  | Jan 8, 2007 Takeda Pharmaceuticals North America Names Vice President of Human Resources and Administration |  |
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 |  | Nov 13, 2006 New Data Show ACTOS® (pioglitazone HCl) Halted Progression of Atherosclerosis as Indicated by CIMT in Patients With Type 2 Diabetes |  |
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 |  | Nov 7, 2006 duetact™ (pioglitazone HCl and glimepiride) Now Available in U.S. Pharmacies |  |
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 |  | Oct 20, 2006 Takeda Celebrates U.S. Growth with Grand Opening of New Home Office |  |
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 |  | Oct 16, 2006 Takeda to Sponsor The LaSalle Bank Chicago Marathon |  |
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 |  | Sep 3, 2006 New Analyses Show ACTOS® (pioglitazone HCl) Reduced Risk of Secondary Stroke by Almost 50 Percent in High-Risk Type 2 Diabetes Patients |  |
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 |  | Jul 31, 2006 FDA Approves Duetact TM (pioglitazone HCl and glimepiride) for the Treatment of Type 2 Diabetes |  |
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 |  | Jun 12, 2006 New Results from the Landmark PROactive Trial Found That ACTOS® (pioglitazone HCl) Reduced the Occurrence of Major Adverse Cardiovascular Events |  |
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 |  | Jun 12, 2006 Cephalon and Takeda Announce Agreement to Co-Promote PROVIGIL® in the United States |  |
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 |  | Jun 9, 2006 ACTOS® (pioglitazone HCl) To Be Studied In New Trial Investigating Its Effects On Atherosclerosis In Patients With Type 2 Diabetes |  |
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 |  | May 22, 2006 New Study Finds that Ramelteon Shows Potential for Circadian Phase Shifting |  |
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 |  | May 22, 2006 New Study Demonstrates that AMITIZA TM(lubiprostone) May Help Improve Symptoms of Irritable Bowel Syndrome with Constipation |  |
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 |  | May 22, 2006 AMITIZA TM(lubiprostone) Shown Effective and Well-Tolerated |  |
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 |  | Apr 25, 2006 AMITIZATM(lubiprostone), the First Selective Chloride Channel Activator for the Treatment of Chronic Idiopathic Constipation, Launches in the United States |  |
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 |  | Apr 3, 2006 Takeda Submits New Drug Application for Extended-Release Type 2 Diabetes Medication, ACTOplus met TM(pioglitazone HCl and metformin HCl) |  |
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 |  | Feb 22, 2006 Takeda Wins Patent Infringement Litigation against ANDA Filers for Generic ACTOS® |  |
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 |  | Jan 31, 2006 Sucampo Obtains FDA Approval for AMITIZATM (lubiprostone) Capsules as Treatment for Chronic Idiopathic Constipation in Adults |  |
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 |  | Nov 22, 2005 Takeda Pharmaceuticals North America Names Chief Compliance Officer |  |
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 |  | Nov 16, 2005 New Data Shows Takeda's ACTOS® (pioglitazone HCl) Reduced Heart Attacks by 28 Percent in People with Type 2 Diabetes |  |
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 |  | Oct 26, 2005 Talented Local Students Receive Scholarships for Scientific Advancement Takeda Sponsors 2005-06 ARCS Scholarship Recipients |  |
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 |  | Sep 20, 2005 PROactive Study Shows Takeda's ACTOS® (pioglitazone HCl) Reduced Heart Attacks, Strokes and Deaths in Patients With Type 2 Diabetes |  |
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 |  | Aug 29, 2005 ACTOplus metTM (pioglitazone HCl and metformin HCl) Approved by the FDA for Type 2 Diabetes |  |
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 |  | Jul 22, 2005 FDA Approved ROZEREM TM(ramelteon), First and Only Non-Scheduled Prescription Sleep Medication |  |
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 |  | Jun 11, 2005 Diabetes Drug ACTOS® (pioglitazone HCl) Showed Anti-Inflammatory Effects |  |
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 |  | May 17, 2005 Older Adults with Insomnia Report Falling Asleep Faster with Ramelteon |  |
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 |  | May 17, 2005 Phase III Clinical Program Evaluates Lubiprostone for the Treatment of Constipation-Predominant Irritable Bowel Syndrome |  |
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 |  | Oct 29, 2004 Takeda Submits New Drug Application for Combination Type 2 Diabetes Medication, Actoplus MetTM (pioglitazone HCl and metformin HCl) |  |
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 |  | Oct 7, 2004 Takeda Announces Partnership with BioNumerik to Market Tavocept TM, Phase 3 Chemoprotective Agent, in North America |  |
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 |  | Sep 24, 2004 Takeda Submits New Drug Application for Ramelteon, an Investigational Sleep Drug |  |
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 |  | Jun 28, 2004 Landmark PROactive Trial Investigates Effect of ACTOS® (pioglitazone HCl) on Cardiovascular Disease Progression |  |
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 |  | Jun 5, 2004 ACTOS® (pioglitazone HCl) Shows Sustained Efficacy Throughout Two-Year Period in Patients with Type 2 Diabetes |  |
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 |  | Jun 5, 2004 Studies Show ACTOS ® (pioglitazone HCl) Has Positive Effects on Various Components of Dyslipidemia |  |
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 |  | Apr 30, 2004 Combination Therapy with ACTOS® (pioglitazone HCl) Shown to Improve Components of Diabetic Dyslipidemia |  |
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 |  | Jan 6, 2004 Takeda Establishes Global Research and Development Center |  |
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 |  | Nov 4, 2003 Kos Pharmaceuticals and Takeda Pharmaceuticals North America Announce Multi-Year Co-Promotion Agreement for Niaspan and Advicor |  |
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 |  | Oct 21, 2003 Takeda Files Patent Infringement Litigation Against ANDA Submissionsfor Generic Pioglitazone |  |
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 |  | Oct 20, 2003 Takeda Pharmaceuticals North America Shares Early Stage Data on ramelteon, formerly known as TAK-375 |  |
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 |  | Oct 17, 2003 Employers Seek New Ways to Offer Workers Prescription Drug Benefits |  |
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 |  | Jun 14, 2003 New Studies Demonstrate Long-Term Efficacy of ACTOS®, Stability of TZD Therapy |  |
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 |  | Jun 13, 2003 Takeda Pharmaceuticals North America Provides Grant to Support Diabetes Research |  |
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 |  | May 21, 2003 Takeda Pharmaceuticals North America Shares Early Stage Data on Sleep Compound, TAK-375 |  |
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 |  | Apr 1, 2003 Takeda Pharmaceuticals North America Initiates Cardiac Clinical Trials |  |
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 |  | Mar 13, 2003 TPNA Expands Sales Organization To Include Medical Center Sales Force |  |
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 |  | Jan 21, 2003 Dr. Mehmood Khan Joins TPNA as Vice President, Medical and Scientific Affairs |  |
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